کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020283 1580401 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reciprocal interaction between the suprachiasmatic nucleus and the immune system tunes down the inflammatory response to lipopolysaccharide
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Reciprocal interaction between the suprachiasmatic nucleus and the immune system tunes down the inflammatory response to lipopolysaccharide
چکیده انگلیسی


- There is a day night rhythm in the cytokine response to LPS that depends on the SCN.
- The SCN is activated by a peripheral injection of LPS.
- Lesioning the SCN causes a 10 fold increase in the immune response.
- The SCN inhibits the inflammatory response to LPS.

Several studies have shown circadian variations in the response of the immune system suggesting a role of the suprachiasmatic nucleus (SCN). Here we show that lipopolysaccharide (LPS) administration in the beginning of the active period induced more severe responses in temperature and cytokines than LPS given in the rest period. Moreover night administered LPS increased SCN basal neuronal activity indicating a direct influence of inflammation on the SCN. Bilateral lesions of the SCN resulted in an increased inflammatory response to LPS demonstrating that an interaction between the SCN and the immune system modulates the intensity of the inflammatory response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 273, Issues 1–2, 15 August 2014, Pages 22-30
نویسندگان
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