کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020395 | 1580397 | 2014 | 10 صفحه PDF | دانلود رایگان |
- Activation of pro- and antinociceptive factors is observed.
- Minocycline inhibits upregulation of IL-6, -18, and MMP-9 mRNA in spinal cord.
- Minocycline inhibits upregulation of IL-6, -18, -10, MMP-2, -9, and TIMP-1 mRNA in DRG.
- Minocycline and MMP-9 Inh.I exert better analgesic effects than does SB203580.
- Minocycline restores the equilibrium between the pro- and antinociceptive factors.
In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline diminished the pronociceptive (IL-6, IL-18), but not antinociceptive (IL-1alpha, IL-4, IL-10) cytokines at the spinal cord level. In vitro primary cell culture studies have shown that MMP-9, TIMP-1, IL-1beta, IL-1alpha, IL-6, IL-10, and IL-18 are of microglial origin. Minocycline reduces the production of pronociceptive factors, resulting in a more potent antinociceptive effect. This change in the ratio between pro- and antinociceptive factors, in favour of the latter may be the mechanism of minocycline analgesia in neuropathy.
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Journal: Journal of Neuroimmunology - Volume 277, Issues 1â2, 15 December 2014, Pages 57-66