A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

- Boosting of WSN-WT primed mice with WSN-Aβ1-10 inhibits anti-Aβ antibody responses.
- Boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral antibody responses.
- Boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral T cell responses.
- Inhibition is associated with expression of Aβ1-10 within the context of an influenza virus.

Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine.These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.