کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6020624 | 1580412 | 2013 | 7 صفحه PDF | دانلود رایگان |
- IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels.
- IL-17 was specifically distributed in the innate and adaptive immunity cells.
- IL-17 may be involved in the epileptogenicity of cortical tubers in TSC.
The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC.
Journal: Journal of Neuroimmunology - Volume 262, Issues 1â2, 15 September 2013, Pages 85-91