ALCAM - Novel multiple sclerosis locus interfering with HLA-DRB1*1501

Moreover, we demonstrated that two ALCAM polymorphisms, rs11559013 and rs34926152, although not associated with MS itself, modify HLA-DRB1*1501 effect. Results obtained from logistic regression analysis showed five-fold lower risk for MS for both rs11559013GA/HLA-DRB1*1501+ and rs34926152GT/HLA-DRB1*1501+ individuals. This observations may suggest protective role against MS for both rs11559013GA and rs34926152GT genotypes in HLA-DRB1*1501 positive individuals.