The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis

► Chemokine signaling via CCR4/CCR6 receptors play a role in the development of EAE. ► IL-6 and IL-17 production are promoted by CCR4/CCR6 signaling. ► CCR4/CCR6 expression by T lymphocytes is presumably of key importance. ► CCR6 and CCR4 might be a therapeutic target of multiple sclerosis.