کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020763 1580420 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationBeta-adrenergic receptor activation primes microglia cytokine production
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Short communicationBeta-adrenergic receptor activation primes microglia cytokine production
چکیده انگلیسی

Exaggerated pro-inflammatory cytokine production by primed microglia is thought to mediate pathology during stress, aging, and neurodegeneration. Recently, it was demonstrated that beta-adrenergic receptor (β-AR) antagonism prevents priming of microglia in mice exposed to chronic stress. To determine if β-AR stimulation is sufficient to prime microglia, rats were intra-cerebroventricularly administered isoproterenol (β-AR agonist) or vehicle and 24 h later hippocampal microglia were placed in culture with media or LPS. Prior isoproterenol treatment significantly enhanced IL-1β and IL-6, but not TNF-α production following LPS stimulation. These data suggest that central β-AR stimulation is sufficient to prime microglia cytokine responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 254, Issues 1–2, 15 January 2013, Pages 161-164
نویسندگان
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