کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020850 | 1580424 | 2012 | 4 صفحه PDF | دانلود رایگان |

Previous reports of multiple sclerosis (MS) with autoantibodies might include neuromyelitis optica (NMO). We investigated the frequency of autoreactive antibodies (AR) in both MS and NMO. Systemic lupus erythematosus (SLE)-associated autoantibodies such as anti-Sm antibodies, anti-single stranded DNA antibodies and lupus anticoagulants were only identified in MS, whereas SLE itself is more commonly associated with NMO. Moreover, when magnetic resonance imaging features between autoreactive antibody-positive (AR(+))MS and -negative (AR(â))MS were compared, AR(+)MS cases showed significantly fewer than 3 periventricular lesions compared to AR(â)MS cases. These results may indicate different pathogenetic mechanisms underlying AR(+)MS and AR(â)MS.
Journal: Journal of Neuroimmunology - Volume 250, Issues 1â2, 15 September 2012, Pages 111-114