کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020850 1580424 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan
چکیده انگلیسی

Previous reports of multiple sclerosis (MS) with autoantibodies might include neuromyelitis optica (NMO). We investigated the frequency of autoreactive antibodies (AR) in both MS and NMO. Systemic lupus erythematosus (SLE)-associated autoantibodies such as anti-Sm antibodies, anti-single stranded DNA antibodies and lupus anticoagulants were only identified in MS, whereas SLE itself is more commonly associated with NMO. Moreover, when magnetic resonance imaging features between autoreactive antibody-positive (AR(+))MS and -negative (AR(−))MS were compared, AR(+)MS cases showed significantly fewer than 3 periventricular lesions compared to AR(−)MS cases. These results may indicate different pathogenetic mechanisms underlying AR(+)MS and AR(−)MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 250, Issues 1–2, 15 September 2012, Pages 111-114
نویسندگان
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