کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020956 | 1580427 | 2012 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats](/preview/png/6020956.png)
In the present study, we investigated how increased sympathetic tone during middle-age affects the splenic sympathetic neurotransmission. Fifteen-month-old (M) F344 rats received rilmenidine (0, 0.5 or 1.5 mg/kg/day, i.p. for 90 days) to lower sympathetic tone. Controls for age were untreated 3 or 18 M rats. We report that rilmenidine (1) reduced plasma and splenic norepinephrine concentrations and splenic norepinephrine turnover, and partially reversed the sympathetic nerve loss; and (2) increased β-adrenergic receptor (β-AR) density and β-AR-stimulated cAMP production. Collectively, these findings suggest a protective effect of lowering sympathetic tone on sympathetic nerve integrity, and enhanced sympathetic neurotransmission in secondary immune organs.
Journal: Journal of Neuroimmunology - Volume 247, Issues 1â2, 15 June 2012, Pages 38-51