کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020996 1580439 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis
چکیده انگلیسی
Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology. Utilizing a novel combination of short-term culture, CFSE-based sorting and anchored PCR, we evaluated clonal compositions of neuroantigen-targeting T-cells from RRMS patients and controls. CDR3 region analysis of TCRβ chains revealed biased use of specific TCRBV-bearing CD4+ clones. CD8+ clones showed homology to published TCR from CNS-infiltrating T-cells in MS lesions. These studies are the first description of TCR usage of CNS-specific CD8+ T-cells and provide insights into their potential regulatory role in disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 234, Issues 1–2, May 2011, Pages 131-140
نویسندگان
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