کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6021048 1580446 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study
چکیده انگلیسی

We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 227, Issues 1–2, 8 October 2010, Pages 185-189
نویسندگان
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