کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6021081 1580441 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair
چکیده انگلیسی
Mice deficient in classical major histocompatibility complex class I (MHCI) have aberrations in neurodevelopment. The consequences of upregulated neuronal MHCI expression have not been examined. We found that transgenic C57Bl/6 mice that are engineered to express higher levels of self-Db on their CNS neurons have alterations in their hippocampal morphology and retinogeniculate projections, as well as impaired neurorepair responses. Thus, enhanced neuronal classical MHCI expression can lead to aberrations in neural circuitry and neurorepair. These findings complement a growing body of knowledge concerning the neurobiological activities of MHCI and may have potential clinical relevance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 232, Issues 1–2, March 2011, Pages 8-16
نویسندگان
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