کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6021176 1580440 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IRF-1 signaling in central nervous system glial cells regulates inflammatory demyelination
چکیده انگلیسی
The present study provides evidence that interferon regulatory factor 1 (IRF-1) signaling in glial cells is involved in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Using a bone marrow chimera model of EAE, we demonstrated that CNS IRF-1 regulates inflammatory demyelination and disease severity independently of the peripheral immune cells. In addition, we identified Caspase 1, a pro-inflammatory and pro-apoptotic molecule, as an important transcriptional target of IRF-1. The findings of our study indicate that IRF-1 signaling in glial cells serves as a final common pathway of inflammatory demyelination and may have important clinical implications in MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 233, Issues 1–2, April 2011, Pages 147-159
نویسندگان
, , , , , , ,