کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
602275 | 879970 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide]-g-poly(l-lactide) graft copolymers Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide]-g-poly(l-lactide) graft copolymers](/preview/png/602275.png)
Biodegradable amphiphilic graft copolymers with different compositions were synthesized by grafting poly(l-lactide) (PLLA) sequences onto a water-soluble poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide] (PHEA) backbone. The critical micelle concentration (CMC) of the graft polymers was determined by fluorescence probe technique. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the graft polymers were proved to have low cytotoxicity. Based on the specific physicochemical property of the graft copolymers, submicron sized microsphere drug delivery systems were prepared by a very convenient “ultrasonic dispersion method”, which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. A hydrophobic drug, prednisone acetate, was encapsulated into polymeric microspheres and the in vitro drug release was studied.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 61, Issue 2, 15 February 2008, Pages 164–169