کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6023091 | 1580867 | 2016 | 58 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of a spaceflight analog environment on brain connectivity and behavior
ترجمه فارسی عنوان
اثرات یک محیط آنالوگ فضایی بر ارتباط و رفتار مغز
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کلمات کلیدی
استراحت تخت، آنالوگ فضایی میکروگرامیت، عملکرد مغز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Sensorimotor functioning is adaptively altered following long-duration spaceflight. The question of whether microgravity affects other central nervous system functions such as brain network organization and its relationship with behavior is largely unknown, but of importance to the health and performance of astronauts both during and post-flight. In the present study, we investigate the effects of prolonged exposure to an established spaceflight analog on resting state brain functional connectivity and its association with behavioral changes in 17 male participants. These bed rest participants remained in bed with their heads tilted down six degrees below their feet for 70 consecutive days. Resting state functional magnetic resonance imaging (rs-fMRI) and behavioral data were obtained at seven time points averaging around: 12 and 8Â days prior to bed rest; 7, 50, and 70Â days during bed rest; and 8 and 12Â days after bed rest. To assess potential confounding effects due to scanning interval or task practice, we also acquired rs-fMRI and behavioral measurements from 14 control participants at four time points. 70Â days of head-down tilt (HDT) bed rest resulted in significant changes in the functional connectivity of motor, somatosensory, and vestibular areas of the brain. Moreover, several of these network alterations were significantly associated with changes in sensorimotor and spatial working memory performance, which suggests that neuroplasticity mechanisms may facilitate adaptation to the microgravity analog environment. The findings from this study provide novel insights into the underlying neural mechanisms and operational risks of spaceflight analog-related changes in sensorimotor performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 141, 1 November 2016, Pages 18-30
Journal: NeuroImage - Volume 141, 1 November 2016, Pages 18-30
نویسندگان
Kaitlin Cassady, Vincent Koppelmans, Patricia Reuter-Lorenz, Yiri De Dios, Nichole Gadd, Scott Wood, Roy Riascos Castenada, Igor Kofman, Jacob Bloomberg, Ajitkumar Mulavara, Rachael Seidler,