کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6023225 | 1580873 | 2016 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of cortical shape in the human brain from 6 to 24Â months of age via a novel measure of shape complexity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
The quantification of local surface morphology in the human cortex is important for examining population differences as well as developmental changes in neurodegenerative or neurodevelopmental disorders. We propose a novel cortical shape measure, referred to as the 'shape complexity index' (SCI), that represents localized shape complexity as the difference between the observed distributions of local surface topology, as quantified by the shape index (SI) measure, to its best fitting simple topological model within a given neighborhood. We apply a relatively small, adaptive geodesic kernel to calculate the SCI. Due to the small size of the kernel, the proposed SCI measure captures fine differences of cortical shape. With this novel cortical feature, we aim to capture comparatively small local surface changes that capture a) the widening versus deepening of sulcal and gyral regions, as well as b) the emergence and development of secondary and tertiary sulci. Current cortical shape measures, such as the gyrification index (GI) or intrinsic curvature measures, investigate the cortical surface at a different scale and are less well suited to capture these particular cortical surface changes. In our experiments, the proposed SCI demonstrates higher complexity in the gyral/sulcal wall regions, lower complexity in wider gyral ridges and lowest complexity in wider sulcal fundus regions. In early postnatal brain development, our experiments show that SCI reveals a pattern of increased cortical shape complexity with age, as well as sexual dimorphisms in the insula, middle cingulate, parieto-occipital sulcal and Broca's regions. Overall, sex differences were greatest at 6Â months of age and were reduced at 24Â months, with the difference pattern switching from higher complexity in males at 6Â months to higher complexity in females at 24Â months. This is the first study of longitudinal, cortical complexity maturation and sex differences, in the early postnatal period from 6 to 24Â months of age with fine scale, cortical shape measures. These results provide information that complement previous studies of gyrification index in early brain development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 135, 15 July 2016, Pages 163-176
Journal: NeuroImage - Volume 135, 15 July 2016, Pages 163-176
نویسندگان
Sun Hyung Kim, Ilwoo Lyu, Vladimir S. Fonov, Clement Vachet, Heather C. Hazlett, Rachel G. Smith, Joseph Piven, Stephen R. Dager, Robert C. Mckinstry, John R. Jr., Alan C. Evans, D. Louis Collins, Kelly N. Botteron, Robert T. Schultz, Guido Gerig,