کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6023292 1580874 2016 41 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional connectivity and network analysis of midbrain and brainstem nuclei
ترجمه فارسی عنوان
قابلیت اتصال و تجزیه و تحلیل شبکه میان هسته و مغز است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی
By means of univariate functional connectivity and graph-based analysis, we show that dopaminergic midbrain centers and the serotonergic dorsal raphe nucleus (DRN) are functionally integrated with the default mode network (DMN), whereas the remaining serotonergic raphe nuclei and the noradrenergic locus coeruleus are functionally integrated with the executive-control network (ECN). The majority of midbrain/brainstem nuclei show a high level of connectedness to other network modules classifying these nuclei as “connector” hubs. The additionally applied probabilistic independent component analysis (PICA) broadly corresponded with the results of the GT analysis, describing similar functionally-relevant cortical networks. Since monoaminergic neurotransmission is essential to neocortical function, and represents an important target for pharmacotherapy, our novel findings contribute to a comprehensive understanding of the functional organization of the human brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 134, 1 July 2016, Pages 53-63
نویسندگان
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