کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6024004 1580880 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of magnetization transfer on T1 contrast in human brain white matter
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Effects of magnetization transfer on T1 contrast in human brain white matter
چکیده انگلیسی
MRI based on T1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T1 relaxation rates is difficult due to the complexity of the contrast mechanism and dependence on experimental details. In this work, we perform simulations and inversion-recovery MRI measurements at 3 T and 7 T to show that substantial measurement variability results from unintended and uncontrolled perturbation of the magnetization of MRI-invisible 1H protons of lipids and macromolecules. This results in bi-exponential relaxation, with a fast component whose relative contribution under practical conditions can reach 20%. This phenomenon can strongly affect apparent relaxation rates, affect contrast between tissue types, and result in contrast variations over the brain. Based on this novel understanding, ways are proposed to minimize this experimental variability and its effect on T1 contrast, quantification accuracy and reproducibility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 128, March 2016, Pages 85-95
نویسندگان
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