کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6024451 1580887 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information
چکیده انگلیسی
The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, most likely because striatal GABA promotes response selection. In contrast, the modulation of response conflict by proprioceptive information is closely related to thalamic GABA concentrations with higher concentration being related to a smaller response conflict effect. The most likely explanation for this finding is that the thalamus is involved in the integration of sensorimotor, attentional, and cognitive information for the purpose of response formation. Yet, this effect in the thalamus vanishes when controls and PD patients were analyzed separately.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 120, 15 October 2015, Pages 36-42
نویسندگان
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