Physiological noise compensation in gradient-echo myelin water imaging

- Physiological noise induced substantial errors in GRE-myelin water imaging.
- Saturation RF pulses were used to reduce inflow noise.
- B0 navigator echoes were used to reduce respiratory noise.
- These compensations improved the quality and reproducibility of GRE-MWI.

In MRI, physiological noise which originates from cardiac and respiratory functions can induce substantial errors in detecting small signals in the brain. In this work, we explored the effects of the physiological noise and their compensation methods in gradient-echo myelin water imaging (GRE-MWI). To reduce the cardiac function induced inflow noise, flow saturation RF pulses were applied to the inferior portion of the head, saturating inflow blood signals. For the respiratory function induced B0 fluctuation compensation, a navigator echo was acquired, and respiration induced phase errors were corrected during reconstruction. After the compensations, the resulting myelin water images show substantially improved image quality and reproducibility. These improvements confirm the importance and usefulness of the physiological noise compensations in GRE-MWI.