کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6025535 | 1580897 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A human post-mortem brain model for the standardization of multi-centre MRI studies
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کلمات کلیدی
qMRIMP-RAGESNRMTRVBMEPIQuantitative MRI - MRI کمیStandardization - استانداردسازیproton density - تراکم پروتونecho planar imaging - تصویر برداری اکو فلاریRadiofrequency - فرکانس رادیوییgrey matter - ماده خاکستریwhite matter - ماده سفیدPost-mortem brain - مغز پس از مرگvoxel-based morphometry - مورفومتری مبتنی بر واکسلmagnetization transfer ratio - نسبت انتقال مغناطیسیSignal-to-noise ratio - نسبت سیگنال به نویز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Multi-centre MRI studies of the brain are essential for enrolling large and diverse patient cohorts, as required for the investigation of heterogeneous neurological and psychiatric diseases. However, the multi-site comparison of standard MRI data sets that are weighted with respect to tissue parameters such as the relaxation times (T1, T2) and proton density (PD) may be problematic, as signal intensities and image contrasts depend on site-specific details such as the sequences used, imaging parameters, and sensitivity profiles of the radiofrequency (RF) coils. Water or gel phantoms are frequently used for long-term and/or inter-site quality assessment. However, these phantoms hardly mimic the structure, shape, size or tissue distribution of the human brain. The goals of this study were: (1) to validate the long-term stability of a human post-mortem brain phantom, performing quantitative mapping of T1, T2, and PD, and the magnetization transfer ratio (MTR) over a period of 18Â months; (2) to acquire and analyse data for this phantom and the brain of a healthy control (HC) in a multi-centre study for MRI protocol standardization in four centres, while conducting a voxel-wise as well as whole brain grey (GM) and white matter (WM) tissue volume comparison. MTR, T2, and the quotient of PD in WM and GM were stable in the post-mortem brain with no significant changes. T1 was found to decrease from 267/236Â ms (GM/WM) to 234/216Â ms between 5 and 17Â weeks post embedment, stabilizing during an 18-month period following the first scan at about 215/190Â ms. The volumetric measures, based on T1-weighted MP-RAGE images obtained at all participating centres, revealed inter- and intra-centre variations in the evaluated GM and WM volumes that displayed similar trends in both the post-mortem brain as well as the HC. At a confidence level of 95%, brain regions such as the brainstem, deep GM structures as well as boundaries between GM and WM tissues were found to be less reproducible than other brain regions in all participating centres. The results demonstrate that a post-mortem brain phantom may be used as a reliable tool for multi-centre MR studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 110, 15 April 2015, Pages 11-21
Journal: NeuroImage - Volume 110, 15 April 2015, Pages 11-21
نویسندگان
Amgad Droby, Carsten Lukas, Anne Schänzer, Isabella Spiwoks-Becker, Antonio Giorgio, Ralf Gold, Nicola De Stefano, Harald Kugel, Michael Deppe, Heinz Wiendl, Sven G. Meuth, Till Acker, Frauke Zipp, Ralf Deichmann,