کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6025636 | 1580898 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rhythmic 3-4Â Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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![عکس صفحه اول مقاله: Rhythmic 3-4Â Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures Rhythmic 3-4Â Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures](/preview/png/6025636.png)
چکیده انگلیسی
Absence seizures are transient episodes of impaired consciousness accompanied by 3-4Â Hz spike-wave discharge on electroencephalography (EEG). Human functional magnetic resonance imaging (fMRI) studies have demonstrated widespread cortical decreases in the blood oxygen-level dependent (BOLD) signal that may play an important role in the pathophysiology of these seizures. Animal models could provide an opportunity to investigate the fundamental mechanisms of these changes, however they have so far failed to consistently replicate the cortical fMRI decreases observed in human patients. This may be due to important differences between human seizures and animal models, including a lack of cortical development in rodents or differences in the frequencies of rodent (7-8Â Hz) and human (3-4Â Hz) spike-wave discharges. To examine the possible contributions of these differences, we developed a ferret model that exhibits 3-4Â Hz spike-wave seizures in the presence of a sulcated cortex. Measurements of BOLD fMRI and simultaneous EEG demonstrated cortical fMRI increases during and following spike-wave seizures in ferrets. However unlike human patients, significant fMRI decreases were not observed. The lack of fMRI decreases was consistent across seizures of different durations, discharge frequencies, and anesthetic regimes, and using fMRI analysis models similar to human patients. In contrast, generalized tonic-clonic seizures under the same conditions elicited sustained postictal fMRI decreases, verifying that the lack of fMRI decreases with spike-wave was not due to technical factors. These findings demonstrate that 3-4Â Hz spike-wave discharge in a sulcated animal model does not necessarily produce fMRI decreases, leaving the mechanism for this phenomenon open for further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 109, 1 April 2015, Pages 368-377
Journal: NeuroImage - Volume 109, 1 April 2015, Pages 368-377
نویسندگان
Mark W. Youngblood, William C. Chen, Asht M. Mishra, Sheila Enamandram, Basavaraju G. Sanganahalli, Joshua E. Motelow, Harrison X. Bai, Flavio Frohlich, Alexandra Gribizis, Alexis Lighten, Fahmeed Hyder, Hal Blumenfeld,