کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6025995 | 1188677 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heritability of head motion during resting state functional MRI in 462 healthy twins
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کلمات کلیدی
MFCICCSPCITCIFCIPCMTCResting state fMRI - fMRI حالت استراحتFunctional connectivity - اتصال عملکردی Dizygotic - بیضویResting state - حالت استراحتHead motion - حرکت سرSMA - دبیرستانOccipital cortex - قشر OccipitalInferior frontal cortex - قشر زیر جلدیMiddle frontal cortex - قشر مغزی خاورمیانهInferior temporal cortex - قشر مچ پا پایینInferior parietal cortex - قشر نای پایین ترSuperior parietal cortex - قشر پروتئینی برترTwin study - مطالعه دوقلوBroca's area - منطقه براکاBrodmann area - منطقه بردممنMonozygotic - مونوزیگوتSMA, supplementary motor area - ناحیه حرکتى تکمیلىHeritability - وراثت پذیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD = 3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2 = 42%). Using a sub-sample (N = 35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent “traits” over repeated scans (r = 0.53-0.59); reliability was even higher for the composite metric (r = 0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2¯ = 0.23 (sd = 0.041), BA45: h2¯ = 0.26 (sd = 0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 102, Part 2, 15 November 2014, Pages 424-434
Journal: NeuroImage - Volume 102, Part 2, 15 November 2014, Pages 424-434
نویسندگان
Baptiste Couvy-Duchesne, Gabriëlla A.M. Blokland, Ian B. Hickie, Paul M. Thompson, Nicholas G. Martin, Greig I. de Zubicaray, Katie L. McMahon, Margaret J. Wright,