کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6026277 | 1580905 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BOLD matches neuronal activity at the mm scale: A combined 7Â T fMRI and ECoG study in human sensorimotor cortex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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![عکس صفحه اول مقاله: BOLD matches neuronal activity at the mm scale: A combined 7Â T fMRI and ECoG study in human sensorimotor cortex BOLD matches neuronal activity at the mm scale: A combined 7Â T fMRI and ECoG study in human sensorimotor cortex](/preview/png/6026277.png)
چکیده انگلیسی
High resolution BOLD fMRI has the potential to map activation patterns of small neuronal populations at the scale of cortical columns. However, BOLD fMRI does not measure neuronal activity, but only a correlate thereof, since it measures blood dynamics. To confirm that BOLD activation maps reflect neuronal population activity patterns, a direct comparison with neuro-electrophysiological data from the same cortical patch is necessary. Here, we compare BOLD activation patterns obtained with fMRI at 7Â T to electrophysiological patterns obtained with implanted high density electrocorticography (ECoG) grids in the same patch of human sensorimotor cortex, and with similar resolution (1.5Â mm). We used high spatially sampled high-frequency broadband (HFB) power from ECoG, which reflects local neuronal population activity. The spatial distribution of 7Â T BOLD activation matched the spatial distribution of ECoG HFB-power changes in the covered patch of sensorimotor cortex. BOLD fMRI activation foci were located within 1-3Â mm of the HFB-power ECoG foci. Both methods distinguished individual finger movement activation within a 1Â cm cortical patch, revealing a topographical medial to lateral layout for the little finger to index to thumb. These findings demonstrate that the BOLD signal at 7Â T is strongly correlated with the underlying electrophysiology, and is capable of discriminating patterns of neuronal population activity at a millimeter scale. The results further indicate the utility of 7Â T fMRI for investigation of intra-area organization of function and network dynamics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 101, 1 November 2014, Pages 177-184
Journal: NeuroImage - Volume 101, 1 November 2014, Pages 177-184
نویسندگان
Jeroen C.W. Siero, Dora Hermes, Hans Hoogduin, Peter R. Luijten, Nick F. Ramsey, Natalia Petridou,