کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6026831 | 1580911 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers
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کلمات کلیدی
MCLOctanalBlood oxygenation level dependent (BOLD)LFPGCLBOLDIAAFunctional MRI - افامآرآی یا تصویرسازی تشدید مغناطیسی کارکردیOct - اکتبرfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیblood oxygenation level dependent - سطح اکسیژن خون وابسته استgranule cell layer - لایه سلول گرانولmitral cell layer - لایه سلولی میترالglomerular layer - لنف گلومرولیlocal field potentials - پتانسیل های زمینه محلیolfactory bulb - پیاز بویایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers](/preview/png/6026831.png)
چکیده انگلیسی
Blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), one of the most powerful technologies in neuroscience, measures neural activity indirectly. Therefore, systematic correlation of BOLD signals with other neural activity measurements is critical to understanding and then using the technology. Numerous studies have revealed that the BOLD signal is determined by many factors and is better correlated with local field potentials (LFP) than single/multiple unit firing. The relationship between BOLD and LFP signals under higher spatial resolution is complex and remains unclear. Here, changes of BOLD and LFP signals in the glomerular (GL), mitral cell (MCL), and granular cell layers (GCL) of the olfactory bulb were evoked by odor stimulation and sequentially acquired using high-resolution fMRI and electrode array. The experimental results revealed a rather complex relationship between BOLD and LFP signals. Both signal modalities were increased layer-dependently by odor stimulation, but the orders of signal intensity were significantly different: GLÂ >Â MCLÂ >Â GCL and GCLÂ >Â GLÂ >Â MCL for BOLD and LFP, respectively. During odor stimulation, the temporal features of LFPs were similar for a given band in different layers, but different for different frequency bands in a given layer. The BOLD and LFP signals in the low gamma frequency band correlated the best. This study provides new evidence for the consistency between structure and function in understanding the neurophysiological basis of BOLD signals, but also reminds that caution must be taken in interpreting of BOLD signals in regard to neural activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 95, 15 July 2014, Pages 29-38
Journal: NeuroImage - Volume 95, 15 July 2014, Pages 29-38
نویسندگان
Bo Li, Ling Gong, Ruiqi Wu, Anan Li, Fuqiang Xu,