کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6027639 1580914 2014 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Layer-dependent BOLD and CBV-weighted fMRI responses in the rat olfactory bulb
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Layer-dependent BOLD and CBV-weighted fMRI responses in the rat olfactory bulb
چکیده انگلیسی
The olfactory bulb is a laminarized brain structure involved in odor sensation that has important implications to basic neuroscience research, like mechanisms for neurovascular coupling and early disease diagnosis. To investigate laminar-dependent responses to odor exposure, blood oxygenation level-dependent (BOLD) and cerebral blood volume weighted (CBVw) fMRI with iron oxide nanoparticle contrast agent were obtained with 110 × 110 × 500 μm3 resolution in urethane-anesthetized rats at 9.4 T. The baseline total CBV is the largest at the olfactory bulb surface and midline, and decreases in the deeper layers, while a band of increased microvasculature density is observed at the glomerular, external plexiform and mitral cell layers. With odor exposure, CBVw fMRI is more sensitive and reproducible than BOLD. BOLD fMRI had the greatest activation on the bulb surface, midline, olfactory nerve and glomerular layers, while CBVw activation peaked in glomerular and external plexiform layers, but was still significant in mitral cell layer. Negative BOLD responses were observed in the bulb midline and near large blood vessels. CBVw laminar profiles are similar to the layer-dependent metabolic changes to the same odor exposure reported by previous glucose metabolism studies. Unique activation patterns for two different odor conditions were also differentiated with CBVw fMRI. Our study suggests that CBVw activation better represents the spatial location of metabolic activity in the olfactory bulb than BOLD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 91, 1 May 2014, Pages 237-251
نویسندگان
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