کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
602789 | 879994 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The p53 network: p53 and its downstream genes
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The p53 network: p53 and its downstream genes The p53 network: p53 and its downstream genes](/preview/png/602789.png)
چکیده انگلیسی
The tumor-suppressor gene p531 and its downstream genes consist of a complicated gene network. p53 is a key molecular node in the network, which is activated in response to several cellular signals resulting in the maintenance of genetic stability. Several cellular signals may activate the p53 network. When the expression of P53 is elevated, P53-MDM2 module and the ubiquitin system can accurately regulate the expression level of P53. P53 can bind to specific DNA sequence, activate its downstream genes expression, and control cell-cycle arrest, DNA repair, and apoptosis. Elucidating the function of p53 gene network will help understand the interaction mechanisms of p53 and its downstream genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 55, Issue 1, 15 March 2007, Pages 10–18
Journal: Colloids and Surfaces B: Biointerfaces - Volume 55, Issue 1, 15 March 2007, Pages 10–18
نویسندگان
Kun-Xian Shu, Biao Li, Li-Xiang Wu,