کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6028375 | 1188702 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutamatergic correlates of gamma-band oscillatory activity during cognition: A concurrent ER-MRS and EEG study
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کلمات کلیدی
NMDAfunctional magnetic resonance spectroscopyFunctional MRSfMRS1H-MRSN-methyl-d-aspartateAMPAα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکgamma-aminobutyric acid - اسید گاما آمینو بوتیریکElectroencephalography - الکتروانسافالوگرافیFID - درrepetition suppression - سرکوب تکرارProton magnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسی پروتونfree induction decay - فروپاشی القایی آزادlateral occipital cortex - قشر جانبی گوشه گوشه سمت چپLoc - محلEEG - نوار مغزیGABA - گاباglutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Frequency specific synchronisation of neuronal firing within the gamma-band (30-70Â Hz) appears to be a fundamental correlate of both basic sensory and higher cognitive processing. In-vitro studies suggest that the neurochemical basis of gamma-band oscillatory activity is based on interactions between excitatory (i.e. glutamate) and inhibitory (i.e. GABA) neurotransmitter concentrations. However, the nature of the relationship between excitatory neurotransmitter concentration and changes in gamma band activity in humans remains undetermined. Here, we examine the links between dynamic glutamate concentration and the formation of functional gamma-band oscillatory networks. Using concurrently acquired event-related magnetic resonance spectroscopy and electroencephalography, during a repetition-priming paradigm, we demonstrate an interaction between stimulus type (object vs. abstract pictures) and repetition in evoked gamma-band oscillatory activity, and find that glutamate levels within the lateral occipital cortex, differ in response to these distinct stimulus categories. Importantly, we show that dynamic glutamate levels are related to the amplitude of stimulus evoked gamma-band (but not to beta, alpha or theta or ERP) activity. These results highlight the specific connection between excitatory neurotransmitter concentration and amplitude of oscillatory response, providing a novel insight into the relationship between the neurochemical and neurophysiological processes underlying cognition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 85, Part 2, 15 January 2014, Pages 823-833
Journal: NeuroImage - Volume 85, Part 2, 15 January 2014, Pages 823-833
نویسندگان
NÃall Lally, Paul G. Mullins, Mark V. Roberts, Darren Price, Thomas Gruber, Corinna Haenschel,