کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6028537 | 1580920 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Auditory tracts identified with combined fMRI and diffusion tractography
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کلمات کلیدی
MGBFDRCoGDSIIRNStgCSDBOLDDTIMNIEPIspherical deconvolution - deconvolution کرویConstrained spherical deconvolution - اختلاط کروی محدود شده استMRI - امآرآی یا تصویرسازی تشدید مغناطیسیmedial geniculate body - اندام تناسلیTractography - تراکتوگرافی echo planar imaging - تصویر برداری اکو فلاریdiffusion tensor imaging - تصویربرداری تانسور انتشارMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیdiffusion spectrum imaging - تصویربرداری طیفی انتشارfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیsubstantia nigra - توده سیاهPositron emission tomography - توموگرافی گسیل پوزیترونsuperior temporal gyrus - جورج جادویی عالیblood oxygenation level dependent - سطح اکسیژن خون وابسته استHeschl's gyrus - طوطی هشلAuditory Cortex - قشر شنواییamplitude modulation - مدولاسیون دامنهCentre of gravity - مرکز جاذبهMontreal Neurological Institute - موسسه عصبی مونترالfalse discovery rate - میزان کشف کاذبPAS - نهPET - پتInferior colliculus - کولیکولوس پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 84, 1 January 2014, Pages 562-574
Journal: NeuroImage - Volume 84, 1 January 2014, Pages 562-574
نویسندگان
Faiza Javad, Jason D. Warren, Caroline Micallef, John S. Thornton, Xavier Golay, Tarek Yousry, Laura Mancini,