کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6028791 | 1188705 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin
ترجمه فارسی عنوان
پاسخ سیتوکروم سکسیداز به تغییرات در تحویل اکسیژن مغزی در مغز بزرگسالان، مشخصه مغزی بیشتری را نسبت به هموگلوبین نشان می دهد
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
The redox state of cerebral mitochondrial cytochrome c oxidase monitored with near-infrared spectroscopy (Î[oxCCO]) is a signal with strong potential as a non-invasive, bedside biomarker of cerebral metabolic status. We hypothesised that the higher mitochondrial density of brain compared to skin and skull would lead to evidence of brain-specificity of the Î[oxCCO] signal when measured with a multi-distance near-infrared spectroscopy (NIRS) system. Measurements of Î[oxCCO] as well as of concentration changes in oxygenated (Î[HbO2]) and deoxygenated haemoglobin (Î[HHb]) were taken at multiple source-detector distances during systemic hypoxia and hypocapnia (decrease in cerebral oxygen delivery), and hyperoxia and hypercapnia (increase in cerebral oxygen delivery) from 15 adult healthy volunteers. Increasing source-detector spacing is associated with increasing light penetration depth and thus higher sensitivity to cerebral changes. An increase in Î[oxCCO] was observed during the challenges that increased cerebral oxygen delivery and the opposite was observed when cerebral oxygen delivery decreased. A consistent pattern of statistically significant increasing amplitude of the Î[oxCCO] response with increasing light penetration depth was observed in all four challenges, a behaviour that was distinctly different from that of the haemoglobin chromophores, which did not show this statistically significant depth gradient. This depth-dependence of the Î[oxCCO] signal corroborates the notion of higher concentrations of CCO being present in cerebral tissue compared to extracranial components and highlights the value of NIRS-derived Î[oxCCO] as a brain-specific signal of cerebral metabolism, superior in this aspect to haemoglobin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 85, Part 1, 15 January 2014, Pages 234-244
Journal: NeuroImage - Volume 85, Part 1, 15 January 2014, Pages 234-244
نویسندگان
Christina Kolyva, Arnab Ghosh, Ilias Tachtsidis, David Highton, Chris E. Cooper, Martin Smith, Clare E. Elwell,