کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6028939 | 1580922 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparing neural response to painful electrical stimulation with functional MRI at 3 and 7Â T
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparing neural response to painful electrical stimulation with functional MRI at 3 and 7Â T Comparing neural response to painful electrical stimulation with functional MRI at 3 and 7Â T](/preview/png/6028939.png)
چکیده انگلیسی
Progressing from 3 T to 7 T functional MRI enables marked improvements of human brain imaging in vivo. Although direct comparisons demonstrated advantages concerning blood oxygen level dependent (BOLD) signal response and spatial specificity, these mostly focused on single brain regions with rather simple tasks. Considering that physiological noise also increases with higher field strength, it is not entirely clear whether the advantages of 7 T translate equally to the entire brain during tasks which elicit more complex neuronal processing. Therefore, we investigated the difference between 3 T and 7 T in response to transcutaneous electrical painful and non-painful stimulation in 22 healthy subjects. For painful stimuli vs. baseline, stronger activations were observed at 7 T in several brain regions including the insula and supplementary motor area, but not the secondary somatosensory cortex (p < 0.05 FWE-corrected). Contrasting painful vs. non-painful stimulation limited the differences between the field strengths to the periaqueductal gray (PAG, p < 0.001 uncorrected) due to a similar signal increase at 7 T for both the target and specific control condition in most brain regions. This regional specificity obtained for the PAG at higher field strengths was confirmed by an additional spatial normalization strategy optimized for the brainstem. Here, robust BOLD responses were obtained in the dorsal PAG at 7 T (p < 0.05 FWE-corrected), whereas at 3 T activation was completely missing for the contrast against non-painful stimuli. To summarize, our findings support previously reported benefits obtained at ultra-high field strengths also for complex activation patterns elicited by painful electrical stimulation. However, this advantage depends on the region and even more on the contrast of interest. The greatest gain at 7 T was observed within the small brainstem region of the PAG, where the increased field strength offered marked improvement for the localization of activation foci with high spatial specificity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 82, 15 November 2013, Pages 336-343
Journal: NeuroImage - Volume 82, 15 November 2013, Pages 336-343
نویسندگان
Andreas Hahn, Georg S. Kranz, Eva-Maria Seidel, Ronald Sladky, Christoph Kraus, Martin Küblböck, Daniela M. Pfabigan, Allan Hummer, Arvina Grahl, Sebastian Ganger, Christian Windischberger, Claus Lamm, Rupert Lanzenberger,