کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6028999 | 1580922 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Are high frequency oscillations associated with altered network topology in partial epilepsy?
ترجمه فارسی عنوان
آیا نوسانات فرکانس بالا در ارتباط با توپولوژی تغییر یافته در صرع جزئی است؟
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کلمات کلیدی
اتصال به عملکرد تجزیه و تحلیل شبکه، نظریه گراف، نوسانات فرکانس بالا، صرع لوب صرع،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Neurophysiological studies have reported functional network alterations in epilepsy, most consistently in the theta frequency band. Highly interconnected brain regions (so-called 'hubs') seem to be important in these epileptic networks. High frequency oscillations (HFOs) in intracranial EEG recordings are recently discovered biomarkers that can identify the epileptogenic area and are thought to result from altered neuronal interactions. We studied whether the epileptogenic zone (identified by HFOs and seizure onset zone) is associated with pathological hubs. Bilateral depth electrode recordings from the hippocampus and amygdala were available from twelve patients suspected of temporal lobe epilepsy. HFOs, classified as ripples (80-250Hz) and fast ripples (250-500Hz), and epileptiform spikes were marked for all patients in a five-minute epoch of slow-wave sleep. For each channel, we computed hub-measures from a period without epileptiform spikes and found that the epileptogenic zone was associated with a decreased hub-value in the theta frequency band. The amount of HFOs, especially fast ripples, was negatively correlated with the hub-value per channel. Results from post-hoc analyses of other frequency bands, particularly the broad- and gamma frequency band, pointed in the same direction as the results for the theta frequency band. These findings suggest a pathological functional 'isolation' of the epileptogenic zone in the interictal state.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 82, 15 November 2013, Pages 564-573
Journal: NeuroImage - Volume 82, 15 November 2013, Pages 564-573
نویسندگان
Eric van Diessen, Judith I. Hanemaaijer, Willem M. Otte, Rina Zelmann, Julia Jacobs, Floor E. Jansen, François Dubeau, Cornelis J. Stam, Jean Gotman, Maeike Zijlmans,