Apathy, depression, and motor symptoms have distinct and separable resting activity patterns in idiopathic Parkinson disease

► We evaluate in PD how apathy, depression, and motor severity influence resting fMRI. ► Measure Amplitude of Low Frequency Fluctuation (ALFF). ► Decreased ALFF in left supplementary motor area predicts apathy. ► Increased ALFF in right subgenual cingulated predicts depression. ► Decreased ALFF in right putamen predicts increasing severity of disease.