Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist

► We synthesized a novel dopamine D2 receptor radiotracer, [11C]SV-III-130. ► We conducted microPET imaging of dopamine D2 receptors using [11C]SV-III-130. ► [11C]SV-III-130 binding can be displaced by D2/3 ligand S(−)-eticlopride. ► Dopamine depletion via lorazepam treatment didn't change the binding potential. ► d-Amphetamine induced dopamine increase displaced [11C]SV-III-130 binding.