کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6029366 1580933 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topological properties of large-scale structural brain networks in children with familial risk for reading difficulties
ترجمه فارسی عنوان
خواص توپولوژیکی شبکه های مغزی ساختاری بزرگ در کودکان مبتلا به خطر خانوادگی برای مشکلات خواندن
کلمات کلیدی
دشواری خواندن، نارساخوانی، ناتوانی در یادگیری، تجزیه و تحلیل نمودار، جهان کوچک، شبکه های مغز،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی

Developmental dyslexia is a neurobiological deficit characterized by persistent difficulty in learning to read in children and adults who otherwise possess normal intelligence. Functional and structural connectivity data suggest that developmental dyslexia could be a disconnection syndrome. However, whether abnormalities in connectivity exist in beginning readers at-risk for reading difficulties is unknown. Using graph-theoretical analysis, we investigated differences in global and regional topological properties of structural brain networks in 42 beginning readers with (FH +) and without (FH −) familial risk for reading difficulties. We constructed separate structural correlation networks based on measures of surface area and cortical thickness. Results revealed changes in topological properties in brain regions known to be abnormal in dyslexia (left supramarginal gyrus, left inferior frontal gyrus) in the FH + group mainly in the network constructed from measures of cortical surface area. We also found alterations in topological properties in regions that are not often advertised as dyslexia but nonetheless play important role in reading (left posterior cingulate, hippocampus, and left precentral gyrus). To our knowledge, this is the first report of altered topological properties of structural correlation networks in children at risk for reading difficulty, and motivates future studies that examine the mechanisms underlying how these brain networks may mediate the influences of family history on reading outcome.

► Altered topological properties in structural networks of FH + children ► Reduced centrality in phonological processing regions in FH + surface area network. ► Possible influence of genetic/prenatal factors on FH + surface-area network

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 71, 1 May 2013, Pages 260-274
نویسندگان
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