کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6029628 | 1580927 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Micro-compartment specific T2â relaxation in the brain Micro-compartment specific T2â relaxation in the brain](/preview/png/6029628.png)
- Susceptibility contrast in cerebral white matter shows three T2â relaxation components.
- Field modeling suggests these components originate from distinct water environments.
- Myelin, axonal, and interstitial water each experience characteristic magnetic fields.
- Their contributions may be separated by multi-component fitting of the decay curve.
MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field. In addition, study of the NMR relaxation properties of this signal has indicated contributions from compartmentalized water environments inside and outside the myelin sheath that may be separable. Here we further investigated the effects of water compartmentalization on the MRI signal with the goal of extracting compartment-specific information. By comparing MRI measurements of human and marmoset brain at 7Â T with magnetic field modeling, we show that: (1) water between the myelin lipid bilayers, in the axonal, and in the interstitial space each experience characteristic magnetic field effects that depend on fiber orientation (2) these field effects result in characteristic relaxation properties and frequency shifts for these compartments; and (3) compartmental contributions may be separated by multi-component fitting of the MRI signal relaxation (i.e. decay) curve. We further show the potential application of these findings to the direct mapping of myelin content and assessment of WM fiber integrity with high field MRI.
Journal: NeuroImage - Volume 77, 15 August 2013, Pages 268-278