The human brain pacemaker: Synchronized infra-slow neurovascular coupling in patients undergoing non-pulsatile cardiopulmonary bypass

► We examined infra-slow brain neurovascular coupling during cardiopulmonary bypass. ► Highly synchrony exists between EEG bursts and ISO of BFV during deep anesthesia. ► Highly synchrony exists between EEG-PV and ISO of BFV during moderate anesthesia.► Brain electrical ISO triggers BFV oscillations in the middle cerebral arteries.