An analysis of the use of hyperoxia for measuring venous cerebral blood volume: Comparison of the existing method with a new analysis approach

► The potential of hyperoxic contrast for measuring venous CBV was investigated. ► Simulations were performed to examine sensitivity to physiological variability. ► The existing method was found to be very sensitive to physiological variability. ► A new method was proposed with much reduced sensitivity to physiological variability. ► Measurements of venous CBV with the new method are in line with literature values.