Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [18F]FEDAA1106

► We measured binding potential of translocator protein with [18F]FEDAA1106 PET. ► We evaluated two types of graphical analysis for reliable quantification. ► Graphical methods provide stable binding potential in region-of-interest analysis. ► Graphical methods with wavelet-denoising have a potential for voxel-based estimation.