Cortical responses to amphetamine exposure studied by pCASL MRI and pharmacokinetic/pharmacodynamic dose modeling

► The non-invasive pCASL technique is well suited for longitudinal studies. ► Repeated pCASL measurements can be used to differentiate placebo from amphetamine. ► pCASL and blood plasma conc. can be used to create a PK/PD-model for dose-response.