Mathematical modelling of [11C]-(+)-PHNO human competition studies

► Selective D3 blockade enables clarification of [11C]-(+)-PHNO binding. ► (+)-PHNO mass dose effect and cerebellar binding were detected. ► Mathematical models describe and account for these effects. ► 11C-(+)-PHNO can be used to measure availability of D2 and D3 receptors in human.