کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6030317 1188724 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images
چکیده انگلیسی

The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The segmentation method and the probabilistic maps we have created will provide a foundation for future studies of cerebellar disorders using transgenic mouse models.

► We present a methodology for delineation of the C57BL/6J mouse cerebellum in MRI. ► We have successfully delineated 38 cerebellar and cerebellar-related structures. ► We calculated average volumes and created probabilistic maps for each structure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 62, Issue 3, September 2012, Pages 1408-1414
نویسندگان
, , , , , , , , , , , , ,