کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
603032 | 880010 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An accurate quantitative analysis of polymorphs based on artificial neural networks
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Measurement precision based on homogeneous and accurate standard samples has been reported to result in significant improvement in the sensitivity and accuracy of the quantitative analysis of polymorphic mixtures. The purpose of this study was to further improve the accuracy of the quantitation based on data processing by artificial neural networks (ANNs), using such high quality standard samples. Homogeneous powder mixtures of α- and γ-forms of indomethacin (IMC) at various ratios (0-50% α-form content) were subjected to X-ray powder diffractometry. The two diffraction peaks selected as the best combination in multiple linear regression (MLR) were used in the ANN with an extended Kalman filter as a training algorithm. The results obtained by ANN had better predictive accuracy at lower contents (0-5%) compared to those of MLR. ANNs for the diffraction data based on high quality standard samples provide an extremely precise and accurate quantification for polymorphic mixtures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 49, Issue 2, 1 May 2006, Pages 153-157
Journal: Colloids and Surfaces B: Biointerfaces - Volume 49, Issue 2, 1 May 2006, Pages 153-157
نویسندگان
Takehiro Okumura, Masayuki Nakazono, Makoto Otsuka, Kozo Takayama,