Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity

► There is significant individual variability in the connectivity of the left DLPFC. ► Individual differences in DLPFC connectivity are reproducible across days. ► Individualized TMS targets appear superior to population-based targets. ► Seed maps improve signal/noise compared to small seed regions. ► Individualized targeting is likely of greater benefit with more focal stimulation.