Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

► Estimation of relationship between AZD9272 plasma concentration and occupancy. ► Simultaneous estimation of radioligand kinetics and drug occupancy. ► Simultaneous inclusion of data from two CNS regions and all PET measurements. ► Shown how nonlinear mixed effects modeling can be used to integrate PET data. ► Less need for simplifications and approximations in the analysis.