Brain activation during anticipation of interoceptive threat

► First non-pharmacological imaging study on anticipation of interoceptive threat. ► Anticipation of interoceptive threat activates same network as anticipation of shock. ► Rostral dACC/dmPFC activation correlates with reported concerns about body symptoms. ► High fear participants show stronger activation of the network. ► Innovative method to study anticipation of interoceptive threat in clinical samples.