NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

► Proposed an experimental design and analysis framework for imaging neurite morphology. ► First in vivo demonstration of neurite orientation dispersion and density mapping. ► NODDI estimates disentangle the key factors contributing to fractional anisotropy. ► NODDI protocol is clinically feasible: imaging the whole brain in 30 minutes or less. ► NODDI protocol is simple to implement, consisting of just two HARDI shells.