Automated detection of white matter signal abnormality using T2 relaxometry: Application to brain segmentation on term MRI in very preterm infants

► We automated DEHSI detection in preterm infants using T2 relaxometry. ► We conducted computer simulations to select an optimal detection parameter. ► The proposed method was validated using both computer simulations and in vivo data. ► Dice index was 95% when noise standard deviation is 20 in simulated infant brain. ► Average tissue segmentation improvement by incorporating DEHSI detection was 3.14%.