A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression

► Meta-analysis of 40 neuroimaging studies on cognitive-emotional challenge in MDD. ► Hypoactivity was found in the anterior insular and anterior cingulate cortex. ► Prefrontal regions showed both hypo- and hyperactivity. ► Subcortical activation alterations were identified in the thalamus and striatum.