Serotonin-1A receptor binding is positively associated with gray matter volume - A multimodal neuroimaging study combining PET and structural MRI

► Multimodal assessment using structural MRI and PET with [carbonyl-11C]WAY - 100635. ► 5-HT1A binding is positively associated with GMV in hippocampi and temporal cortices. ► 5-HT1A receptor binding in the midbrain is associated with gray matter in forebrain. ► Neuroplastic properties of 5-HT1A receptors might be involved.